Extending AnchorWave for Multiple Sequence Alignment: A Novel Approach for Comparative Genomics

  1. MSc thesis
  2. ΑΝΔΡΙΑΝΑ ΣΙΕΛΛΗ
  3. Βιοπληροφορική και Νευροπληροφορική (ΒΝΠ)
  4. 8 Μαρτίου 2025
  5. Αγγλικά
  6. 29
  7. ΧΑΡΙΔΗΜΟΣ ΚΟΝΔΥΛΑΚΗΣ
  8. Multiple Sequence Alignment, AnchorWave, Computational Efficiency, Memory Optimization, Comparative Genomics, Plant Genomes, Structural Variations, Bioinformatics
  9. Βιοπληροφορική και Νευροπληροφορική
  10. 18
    • Our method extends AnchorWave to support multiple sequence alignment (MSA),
      enabling the identification of conserved regions across multiple sequences while
      maintaining computational efficiency. By leveraging an anchor-based approach, it
      minimizes the computational overhead typically associated with MSA, making it
      suitable for large-scale genomic studies. The implementation is optimized to run
      on low-capacity resources, ensuring accessibility for researchers working with
      limited computational power. This extension provides a practical and scalable
      solution for comparative genomics, particularly in analyzing plant genomes, which
      often contain complex structural variations and repetitive regions.


  11. Hellenic Open University
  12. Attribution-NonCommercial-NoDerivatives 4.0 Διεθνές