Ports’ operational efficiency is the result of effective management policies that require cooperation among different sections of the public and private sectors. Ports constitute supply chain nodes, where considerable freight is borne to the final destination, augmenting local, regional, national, and international wealth levels. A combination of modalities operations is imported, mainly train and road networks, connecting maritime transportation with the hinterland. Congestion rises after economic, social, and geopolitical events and the sanitary restrictions imposed during the COVID-19 pandemic. Demand rises and falls, and route alterations cause inconvenience in maritime transportation and the global market. The queuing of vessels outside the ports and the increased waiting times affect global trade and prosperity, while multimodal transit, environment, labor conditions, and markets are vulnerable to significant implications. Sufficient capacity, robust automated equipment, human resources expertise, and effective collaboration lead to decent port performance. One step further, slot distribution is implemented to manage the movement of vessels towards ports and terminals. Slot coordination is implemented in ports of high importance for the international supply chain and other modes of transportation and information systems, exploiting its essential benefits. Utilizing data provided by AI tools and devices established onboard and at ports’ operational centres, slots are applied to administer time and capacity efficiently. However, planning port operations according to slot allocation systems is sensitive to factors affecting global society. The shipping industry faces essential disruptions preventing vessels’ routes and timelines from conforming to the slots. Since the smooth operation of the maritime is disturbed by unprojected incidents, immediate information flow is crucial to the competent departments. Interrelating with land modes is supported by high-technology innovations applied through all the functioning stages, contributing to operational optimization. Both road and train modalities present advantages and disadvantages in commodities distribution while constantly evolving simultaneously with maritime trade. The augmentation of the demand for goods is due to transportation demand. Inland and seaborne transportation are derived simultaneously, possessing their share in the global supply chain. On the one hand, high speed combined with a large volume of railways and on the other hand, truck flexibility constitute multimodal transportation options for commodities distribution worldwide. This paper eventually inserts the perspective of a multiple-slot coordination system implemented in multimodal transportation, updated continuously under changes happening in every mode.